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BDBM324689 1'-({5-Chloro-1-[4-(1,1-dioxido-1,2- thiazolidin-2-yl)butyl]-1H-indol-2- yl}methyl)spiro[cyclopropane-1,3'- pyrrolo[2,3-c]pyridin]-2'(1'H)-one::US10189838, Example 7-8

SMILES: Clc1ccc2n(CCCCN3CCCS3(=O)=O)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1

InChI Key: InChIKey=AYGYFSGPERKBKM-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 324689   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix M2-1


(Human respiratory syncytial virus A (strain A2))
BDBM324689
PNG
(1'-({5-Chloro-1-[4-(1,1-dioxido-1,2- thiazolidin-2...)
Show SMILES Clc1ccc2n(CCCCN3CCCS3(=O)=O)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Show InChI InChI=1S/C25H27ClN4O3S/c26-19-4-5-22-18(14-19)15-20(29(22)12-2-1-10-28-11-3-13-34(28,32)33)17-30-23-16-27-9-6-21(23)25(7-8-25)24(30)31/h4-6,9,14-16H,1-3,7-8,10-13,17H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 18n/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...


US Patent US10189838 (2019)

More data for this
Ligand-Target Pair