BDBM325646 US9636336, Example 109::US9636336, Example 37::[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]5-[[[1-(hydroxymethyl)-2-[(1-methyl-4-piperidyl)methoxy]-2-oxo-1-(2-thienyl)ethyl]amino]methyl]thiophene-2-carboxylate

SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNC(CO)(C(=O)OCC2CCN(C)CC2)c2cccs2)s1

InChI Key InChIKey=PDWWFGIELKDDKB-SZVSUXHCSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 325646   

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Chiesi Farmaceutici

US Patent
LigandPNGBDBM325646(US9636336, Example 109 | US9636336, Example 37 | [...)
Affinity DataIC50:  5.5nMAssay Description:Human M3 receptor membranes (15 μg/well) from Perkin Elmer are incubated with 0.52 nM Scopolamine Methyl Chloride, [N-methyl-3H] with or without...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Chiesi Farmaceutici

US Patent
LigandPNGBDBM325646(US9636336, Example 109 | US9636336, Example 37 | [...)
Affinity DataIC50: <1nMAssay Description:PDE4B2 activity is detected using the LANCE Ultra cAMP homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay from Perkin E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Chiesi Farmaceutici

US Patent
LigandPNGBDBM325646(US9636336, Example 109 | US9636336, Example 37 | [...)
Affinity DataIC50:  5.5nMAssay Description:Human M3 receptor membranes (15 μg/well) from Perkin Elmer are incubated with 0.52 nM Scopolamine Methyl Chloride, [N-methyl-3H] with or without...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Chiesi Farmaceutici

US Patent
LigandPNGBDBM325646(US9636336, Example 109 | US9636336, Example 37 | [...)
Affinity DataIC50: <1nMAssay Description:PDE4B2 activity is detected using the LANCE Ultra cAMP homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay from Perkin E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent