BDBM325650 US9636336, Example 44::US9636336, Example 45::[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl]5-[[[2-oxo-1-phenyl-2-(quinuclidin-4-ylmethoxy)ethyl]amino]methyl]thiophene-2-carboxylate

SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2ccc(CNC(C(=O)OCC34CCN(CC3)CC4)c3ccccc3)s2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1

InChI Key InChIKey=CWJNVXDEWVSWIC-LUEXLKCISA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 325650   

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Chiesi Farmaceutici

US Patent
LigandPNGBDBM325650(US9636336, Example 44 | US9636336, Example 45 | [(...)
Affinity DataIC50:  5.5nMAssay Description:Human M3 receptor membranes (15 μg/well) from Perkin Elmer are incubated with 0.52 nM Scopolamine Methyl Chloride, [N-methyl-3H] with or without...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Chiesi Farmaceutici

US Patent
LigandPNGBDBM325650(US9636336, Example 44 | US9636336, Example 45 | [(...)
Affinity DataIC50:  5.5nMAssay Description:PDE4B2 activity is detected using the LANCE Ultra cAMP homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay from Perkin E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Chiesi Farmaceutici

US Patent
LigandPNGBDBM325650(US9636336, Example 44 | US9636336, Example 45 | [(...)
Affinity DataIC50: <1nMAssay Description:Human M3 receptor membranes (15 μg/well) from Perkin Elmer are incubated with 0.52 nM Scopolamine Methyl Chloride, [N-methyl-3H] with or without...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Chiesi Farmaceutici

US Patent
LigandPNGBDBM325650(US9636336, Example 44 | US9636336, Example 45 | [(...)
Affinity DataIC50:  5.5nMAssay Description:PDE4B2 activity is detected using the LANCE Ultra cAMP homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay from Perkin E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent