BDBM325931 US10273223, Compound B-25::US9637472, Compound B-25

SMILES CCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(nc2n(ncc12)C(C)C)C1=CC(C)(C)NC(C)(C)C1

InChI Key InChIKey=VHCGYHWBIWHCAF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 325931   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM325931(US10273223, Compound B-25 | US9637472, Compound B-...)
Affinity DataIC50: <300nMAssay Description:eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM325931(US10273223, Compound B-25 | US9637472, Compound B-...)
Affinity DataIC50: <300nMAssay Description:Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent