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BDBM326204 3-[(3R)-1- (ethoxyacetyl)piperidin-3- yl]-1-(4-phenoxyphenyl)- 1H-pyrazolo[3,4- c]pyridin-7-amine::US9637486, Example 16

SMILES: CCOCC(=O)N1CCC[C@H](C1)c1nn(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccc12

InChI Key: InChIKey=NCXRWBXUUIVAHW-LJQANCHMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326204   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM326204
PNG
(3-[(3R)-1- (ethoxyacetyl)piperidin-3- yl]-1-(4-phe...)
Show SMILES CCOCC(=O)N1CCC[C@H](C1)c1nn(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccc12
Show InChI InChI=1S/C27H29N5O3/c1-2-34-18-24(33)31-16-6-7-19(17-31)25-23-14-15-29-27(28)26(23)32(30-25)20-10-12-22(13-11-20)35-21-8-4-3-5-9-21/h3-5,8-15,19H,2,6-7,16-18H2,1H3,(H2,28,29)/t19-/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.5n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
In this assay, the potency (IC50) of each compound was determined from an eleven point (1:3 serial dilution; final compound concentration range in as...


US Patent US9637486 (2017)

More data for this
Ligand-Target Pair