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BDBM326251 3-(1-(9H-purin-6-yl)pyrrolidin-2-yl)-7-fluoro-2-(pyridin-3-yl)quinoline ::US9637488, 1

SMILES: Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1cccnc1

InChI Key: InChIKey=PELZJDNCZDWFNG-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326251   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326251
PNG
(3-(1-(9H-purin-6-yl)pyrrolidin-2-yl)-7-fluoro-2-(p...)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1cccnc1
Show InChI InChI=1S/C23H18FN7/c24-16-6-5-14-9-17(20(30-18(14)10-16)15-3-1-7-25-11-15)19-4-2-8-31(19)23-21-22(27-12-26-21)28-13-29-23/h1,3,5-7,9-13,19H,2,4,8H2,(H,26,27,28,29)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 27n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair