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BDBM326256 US9637488, 15

SMILES: Nc1ncnc(N2CCCC2c2cc3ccc(F)cc3nc2-c2ccccn2)c1C#N

InChI Key: InChIKey=HJVPRYFFXKEDSN-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326256   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326256
PNG
(US9637488, 15)
Show SMILES Nc1ncnc(N2CCCC2c2cc3ccc(F)cc3nc2-c2ccccn2)c1C#N
Show InChI InChI=1S/C23H18FN7/c24-15-7-6-14-10-16(21(30-19(14)11-15)18-4-1-2-8-27-18)20-5-3-9-31(20)23-17(12-25)22(26)28-13-29-23/h1-2,4,6-8,10-11,13,20H,3,5,9H2,(H2,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 62n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair