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BDBM326257 US9637488, 16

SMILES: Fc1ccc2cc(C3CCCN3c3ncnc4nc[nH]c34)c(nc2c1)-c1ccccn1

InChI Key: InChIKey=DWGPQDAXSIFCLM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326257   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326257
PNG
(US9637488, 16)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4nc[nH]c34)c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18FN7/c24-15-7-6-14-10-16(20(30-18(14)11-15)17-4-1-2-8-25-17)19-5-3-9-31(19)23-21-22(27-12-26-21)28-13-29-23/h1-2,4,6-8,10-13,19H,3,5,9H2,(H,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair