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BDBM326266 US9637488, 26

SMILES: Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1OC(F)(F)F

InChI Key: InChIKey=SSXREHXTUYVIDF-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326266   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326266
PNG
(US9637488, 26)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C25H18F4N6O/c26-15-8-7-14-10-17(19-5-3-9-35(19)24-22-23(31-12-30-22)32-13-33-24)21(34-18(14)11-15)16-4-1-2-6-20(16)36-25(27,28)29/h1-2,4,6-8,10-13,19H,3,5,9H2,(H,30,31,32,33)
PDB
MMDB

NCI pathway
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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 207n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair