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BDBM326270 US9637488, 30

SMILES: COc1ccccc1-c1nc2cc(F)ccc2cc1C1CCCN1c1ncnc(N)c1C#C

InChI Key: InChIKey=AZAUEZOUHAERGI-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326270   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326270
PNG
(US9637488, 30)
Show SMILES COc1ccccc1-c1nc2cc(F)ccc2cc1C1CCCN1c1ncnc(N)c1C#C
Show InChI InChI=1S/C26H22FN5O/c1-3-18-25(28)29-15-30-26(18)32-12-6-8-22(32)20-13-16-10-11-17(27)14-21(16)31-24(20)19-7-4-5-9-23(19)33-2/h1,4-5,7,9-11,13-15,22H,6,8,12H2,2H3,(H2,28,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 4.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair