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BDBM326271 US9637488, 31

SMILES: Fc1ccc2cc(C3CC=CCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1

InChI Key: InChIKey=FXHTUXICSNQKFL-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326271   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM326271
PNG
(US9637488, 31)
Show SMILES Fc1ccc2cc(C3CC=CCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1
Show InChI InChI=1S/C25H19FN6/c26-18-10-9-17-12-19(22(31-20(17)13-18)16-6-2-1-3-7-16)21-8-4-5-11-32(21)25-23-24(28-14-27-23)29-15-30-25/h1-7,9-10,12-15,21H,8,11H2,(H,27,28,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 103n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair