BDBM326316 5-{4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcyclohexyl)methyl]- 5H-pyrrolo[3,2- d]pyrimidin-2-yl}-1,3,4- oxadiazol-2(3H)-one::US9637493, 4.5

SMILES C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cncc(Cl)c4)c23)-c2n[nH]c(=O)o2)CC1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326316   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326316(5-{4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcy...)
Affinity DataIC50:  95nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent