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BDBM327829 2-((R)-4-((S)-(3-bromophenyl)(phenyl)methyl)-2-methylpiperazin-1-yl)acetic acid::US9663476, Compound 21

SMILES: C[C@@H]1CN(CCN1CC(O)=O)[C@@H](c1ccccc1)c1cccc(Br)c1

InChI Key: InChIKey=OIVVLOMKKYRLKQ-QRWLVFNGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 327829   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))
BDBM327829
PNG
(2-((R)-4-((S)-(3-bromophenyl)(phenyl)methyl)-2-met...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@@H](c1ccccc1)c1cccc(Br)c1
Show InChI InChI=1S/C20H23BrN2O2/c1-15-13-23(11-10-22(15)14-19(24)25)20(16-6-3-2-4-7-16)17-8-5-9-18(21)12-17/h2-9,12,15,20H,10-11,13-14H2,1H3,(H,24,25)/t15-,20+/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.934n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)

More data for this
Ligand-Target Pair