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BDBM327839 US9663476, Compound 48::[(R)-2-methyl-4-[(R)-(3′-methyl-biphenyl-4-yl)-phenyl-methyl]-piperazin-1-yl]-acetic acid

SMILES: C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)-c1cccc(C)c1

InChI Key: InChIKey=UJFSHJIHSJJHAL-JIPXPUAJSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 327839   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))
BDBM327839
PNG
(US9663476, Compound 48 | [(R)-2-methyl-4-[(R)-(3&#...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)-c1cccc(C)c1
Show InChI InChI=1S/C27H30N2O2/c1-20-7-6-10-25(17-20)22-11-13-24(14-12-22)27(23-8-4-3-5-9-23)29-16-15-28(19-26(30)31)21(2)18-29/h3-14,17,21,27H,15-16,18-19H2,1-2H3,(H,30,31)/t21-,27-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 217n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair