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BDBM327843 2-((R)-2-methyl-4-((R)-thiophen-2-yl(3-(trifluoromethyl)phenyl)methyl)-piperazin-1-yl)acetic acid::US9663476, Compound 75

SMILES: C[C@@H]1CN(CCN1CC(O)=O)[C@@H](c1cccs1)c1cccc(c1)C(F)(F)F

InChI Key: InChIKey=YYQMYLPZPJXTOC-FZKQIMNGSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 327843   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))
BDBM327843
PNG
(2-((R)-2-methyl-4-((R)-thiophen-2-yl(3-(trifluorom...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@@H](c1cccs1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N2O2S/c1-13-11-24(8-7-23(13)12-17(25)26)18(16-6-3-9-27-16)14-4-2-5-15(10-14)19(20,21)22/h2-6,9-10,13,18H,7-8,11-12H2,1H3,(H,25,26)/t13-,18-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.20E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair