BindingDB logo
myBDB logout

BDBM327845 (R)-2-(4-(bis(4-chlorophenyl)methyl)-2-methylpiperazin-1-yl)acetic acid::US9663476, Compound 78

SMILES: C[C@@H]1CN(CCN1CC(O)=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1

InChI Key: InChIKey=ZJHQZQOVEORODP-CQSZACIVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 327845   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))
BDBM327845
PNG
((R)-2-(4-(bis(4-chlorophenyl)methyl)-2-methylpiper...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22Cl2N2O2/c1-14-12-24(11-10-23(14)13-19(25)26)20(15-2-6-17(21)7-3-15)16-4-8-18(22)9-5-16/h2-9,14,20H,10-13H2,1H3,(H,25,26)/t14-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 41.1n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair