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BDBM328362 1-((4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)sulfonyl)-1H-indole-3-carbonitrile::US9663498, Example 2

SMILES: COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C#N)c2ccccc12

InChI Key: InChIKey=RGAHPZKGWMVENE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 328362   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM328362
PNG
(1-((4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)sul...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C#N)c2ccccc12
Show InChI InChI=1S/C21H22N4O3S/c1-23-9-11-24(12-10-23)20-13-17(7-8-21(20)28-2)29(26,27)25-15-16(14-22)18-5-3-4-6-19(18)25/h3-8,13,15H,9-12H2,1-2H3
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.590n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair