BindingDB logo
myBDB logout

BDBM328387 5-bromo-3-(difluoromethyl)-1-((4-methoxy-3-(piperazin-1-yl) phenyl)sulfonyl)-1H-indole::US9663498, Example 27

SMILES: COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Br)ccc12

InChI Key: InChIKey=YPOGBVDYAMBEKC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 328387   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM328387
PNG
(5-bromo-3-(difluoromethyl)-1-((4-methoxy-3-(pipera...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Br)ccc12
Show InChI InChI=1S/C20H20BrF2N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-10-13(21)2-4-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.550n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair