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BDBM328401 3-(difluoromethyl)-1-((3-(4-ethylpiperazin-1-yl)-4-methoxyphenyl) sulfonyl)-6-(trifluoromethyl)-1H-indole::US9663498, Example 46

SMILES: CCN1CCN(CC1)c1cc(ccc1OC)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F

InChI Key: InChIKey=WGTDNMGXSHGQQN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 328401   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM328401
PNG
(3-(difluoromethyl)-1-((3-(4-ethylpiperazin-1-yl)-4...)
Show SMILES CCN1CCN(CC1)c1cc(ccc1OC)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C23H24F5N3O3S/c1-3-29-8-10-30(11-9-29)20-13-16(5-7-21(20)34-2)35(32,33)31-14-18(22(24)25)17-6-4-15(12-19(17)31)23(26,27)28/h4-7,12-14,22H,3,8-11H2,1-2H3
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.25n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair