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BDBM328407 6-bromo-3-(difluoromethyl)-1-((4-methoxy-3-(piperazin-1-yl) phenyl)sulfonyl)-1H-indazole::US9663498, Example 57

SMILES: COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1nc(C(F)F)c2ccc(Br)cc12

InChI Key: InChIKey=XACXKXHKYIVBJW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 328407   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM328407
PNG
(6-bromo-3-(difluoromethyl)-1-((4-methoxy-3-(pipera...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1nc(C(F)F)c2ccc(Br)cc12
Show InChI InChI=1S/C19H19BrF2N4O3S/c1-29-17-5-3-13(11-16(17)25-8-6-23-7-9-25)30(27,28)26-15-10-12(20)2-4-14(15)18(24-26)19(21)22/h2-5,10-11,19,23H,6-9H2,1H3
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.580n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair