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BDBM329544 2-(5-(2-methyl-4- (((1S,2S)-2-(quinolin-2- yl)cyclopropyl)methoxy) pyrimidin-5-yl)pyridin-2- yl)propan-2-ol::US9663513, 157

SMILES: Cc1ncc(-c2ccc(nc2)C(C)(C)O)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1

InChI Key: InChIKey=DFLYFNVDNXIMHM-UXHICEINSA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 329544   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329544
PNG
(2-(5-(2-methyl-4- (((1S,2S)-2-(quinolin-2- yl)cycl...)
Show SMILES Cc1ncc(-c2ccc(nc2)C(C)(C)O)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C26H26N4O2/c1-16-27-14-21(18-9-11-24(28-13-18)26(2,3)31)25(29-16)32-15-19-12-20(19)23-10-8-17-6-4-5-7-22(17)30-23/h4-11,13-14,19-20,31H,12,15H2,1-3H3/t19-,20+/m1/s1
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MMDB

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PC cid
PC sid
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US Patent
0.0200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair