BDBM329726 (3S,4R)-1-(1-(2- chloro-6- (trifluoromethyl)benzoyl)- 4-fluoro-1H-indazol-3-yl)- 3-hydroxypiperidine-4- carboxylic acid::US9663522, 6D
SMILES O[C@@H]1CN(CC[C@H]1C(O)=O)c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12
InChI Key InChIKey=GZMOOCYTZMPTMH-MEBBXXQBSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 329726
Affinity DataIC50: 51nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Allosteric inhibition of yeast GAL4 DNA domain-fused RORgammat LBD (97 to 518 residues) (unknown origin) expressed in HEK293T cells after 20 to 22 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair