BDBM330414 N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4, 6-diamine ::US9725439, 16

SMILES COCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC1CN(C1)C(=O)C=C

InChI Key InChIKey=NMYZOLMOXWOLKO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 330414   

TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330414(N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro-4-fluoro...)
Affinity DataIC50:  1.20nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent