BDBM331429 8-[(4,4-Difluorocyclohexyl)(phenyl)methyl]-5-(dimethyl-1H-1,2,3-triazol-5-yl)-11-(4-methylpiperazin-1-yl)-3,8,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene::US9725449, Example 264::US9725449, Example 265

SMILES CN1CCN(CC1)c1ccc2c(n1)n(C(C1CCC(F)(F)CC1)c1ccccc1)c1cc(cnc21)-c1c(C)nnn1C

InChI Key InChIKey=JJUFLTRHFIKPBN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331429   

TargetBromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM331429(8-[(4,4-Difluorocyclohexyl)(phenyl)methyl]-5-(dime...)
Affinity DataIC50: <1nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM331429(8-[(4,4-Difluorocyclohexyl)(phenyl)methyl]-5-(dime...)
Affinity DataIC50: <10nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent