BDBM331666 Preparation of 2-(2-Fluoro-4-{6-[2-(3-fluoro-4-hydroxy-piperidin-1-yl)-ethoxy]-7-methoxy-quinolin-3-yl}-phenyl)-N-[5-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-isoxazol-3-yl]-acetamide::US9725465, Example 87

SMILES COc1cc2ncc(cc2cc1OCCN1CC[C@H](O)[C@@H](F)C1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1

InChI Key InChIKey=CHZMWVKONIEEHB-ZCYQVOJMSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331666   

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM331666(Preparation of 2-(2-Fluoro-4-{6-[2-(3-fluoro-4-hyd...)
Affinity DataKd: <5nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM331666(Preparation of 2-(2-Fluoro-4-{6-[2-(3-fluoro-4-hyd...)
Affinity DataKd: <5nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent