BDBM331907 S)-3-((2-((5-amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-3-yl)(methyl)amino)ethyl)amino)-1,1,1-trifluoropropan-2-ol::US10189859, Compound 147

SMILES CN(CCNC[C@H](O)C(F)(F)F)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=GEMBNJDHHNMORR-JTQLQIEISA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 331907   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM331907(S)-3-((2-((5-amino-6-(2,3-dichlorophenyl)-1,2,4-tr...)
Affinity DataIC50:  1.51E+5nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM331907(S)-3-((2-((5-amino-6-(2,3-dichlorophenyl)-1,2,4-tr...)
Affinity DataIC50: <5.00E+4nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM331907(S)-3-((2-((5-amino-6-(2,3-dichlorophenyl)-1,2,4-tr...)
Affinity DataIC50:  1.79E+5nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM331907(S)-3-((2-((5-amino-6-(2,3-dichlorophenyl)-1,2,4-tr...)
Affinity DataIC50: <5.00E+4nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent