BDBM331977 (R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- methyl)phenyl) ethyl)-1H- imidazol-4-yl) pyrimidin-4 (3H)-one::US10195201, Example 16::US10195201, Example 17

SMILES CC(c1ccc(cc1)C(F)(F)F)n1cnc(c1)-c1cc(=O)[nH]c(C)n1

InChI Key

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 331977   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331977((R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- meth...)
Affinity DataKi:  76nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331977((R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- meth...)
Affinity DataKi:  106nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM331977((R)- or (S)-2- methyl-6-(1-(1- (4-(trifluoro- meth...)
Affinity DataKi:  340nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent