BDBM331988 US10195181, Example 15a::US10195181, Example 15b

SMILES Cc1c(noc1C1CCC[C@H](O1)C(C)(C)C)C(=O)Nc1c(C)n(C)n(C2CCC2)c1=O

InChI Key InChIKey=HSVDEPRFXVRJIG-DJNXLDHESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331988   

TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM331988(US10195181, Example 15a | US10195181, Example 15b)
Affinity DataIC50:  630nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM331988(US10195181, Example 15a | US10195181, Example 15b)
Affinity DataIC50:  290nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent