BDBM33212 pyrazolo pyridine, 11

SMILES CCOC(=O)c1cnc2[nH]ncc2c1N1CCOC(CN)C1

InChI Key InChIKey=RCMLOOJGYJFCJA-UHFFFAOYSA-N

Data  4 IC50  1 Other

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 33212   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
The Institute Of Cancer Research

LigandPNGBDBM33212(pyrazolo pyridine, 11)
Affinity DataIC50:  1.20E+3nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The Institute Of Cancer Research

LigandPNGBDBM33212(pyrazolo pyridine, 11)
Affinity DatapH: 7.5 T: 2°CAssay Description:CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM33212(pyrazolo pyridine, 11)
Affinity DataIC50:  5.00E+4nMAssay Description:Competitive inhibition of human CHK2 using ATP as substrate by DELFIAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
The Institute Of Cancer Research

LigandPNGBDBM33212(pyrazolo pyridine, 11)
Affinity DataIC50:  1.00E+3nMAssay Description:Competitive inhibition of human CHK1 using ATP as substrate by DELFIAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM33212(pyrazolo pyridine, 11)
Affinity DataIC50:  7.40E+4nMpH: 7.4 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed