BDBM332431 4-(1-(2- chloro-6- cyclopropyl- benzoyl)-4- fluoro-1H- indazol-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1AA::US9745265, 1AA

SMILES OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3cccc(F)c23)c(F)c1

InChI Key InChIKey=ITAJZCHZGRGIEJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332431   

TargetNuclear receptor ROR-gamma(Mus musculus)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332431(4-(1-(2- chloro-6- cyclopropyl- benzoyl)-4- fluoro...)
Affinity DataIC50:  2nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332431(4-(1-(2- chloro-6- cyclopropyl- benzoyl)-4- fluoro...)
Affinity DataIC50:  2nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent