BDBM332436 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6- ((2S,6R)-2,6- dimethyl- morpholine-4- carbonyl)-1H- indazol-3-yl)-3- fluorobenzoic acid::US10196354, Example 2B::US9745265, 2B

SMILES C[C@H]1CN(C[C@@H](C)O1)C(=O)c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O

InChI Key InChIKey=FYCDYBZKAVRDMF-GASCZTMLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332436   

TargetNuclear receptor ROR-gamma(Mus musculus)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332436(4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6- ((...)
Affinity DataIC50:  15nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332436(4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6- ((...)
Affinity DataIC50:  15nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent