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BDBM332547 (2E)-3-(4-bromophenyl)-1-{7-[(3-bromophenyl)carbonyl]-2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one::US10196369, Compound C2

SMILES: Brc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)c2cccc(Br)c2)cc1

InChI Key: InChIKey=HVIJQLAUIZJYPF-RMKNXTFCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332547   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332547
PNG
((2E)-3-(4-bromophenyl)-1-{7-[(3-bromophenyl)carbon...)
Show SMILES Brc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C23H22Br2N2O2/c24-19-7-4-17(5-8-19)6-9-21(28)27-15-23(16-27)10-12-26(13-11-23)22(29)18-2-1-3-20(25)14-18/h1-9,14H,10-13,15-16H2/b9-6+
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair