BDBM33255 phthalazine-based compound, 6

SMILES C1CN=C(N1)c1ccc(Nc2nnc(Nc3ccc4CNCCc4c3)c3ccccc23)cc1

InChI Key InChIKey=RMLPTNJYXRIJII-UHFFFAOYSA-N

Data  5 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 33255   

TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50:  1.70E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2 (strain TSV01))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50:  5.50E+4nM Kd:  5.40E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50:  6.20E+3nM Kd:  7.00E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed