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BDBM332556 (2E)-1-{2-[(2,6-dichlorophenyl)methyl]-2,7-diazaspiro[3.5]non-7-yl}-3-(4-bromophenyl)prop-2-en-1-one::US10196369, Compound C11

SMILES: Clc1cccc(Cl)c1CN1CC2(C1)CCN(CC2)C(=O)\C=C\c1ccc(Br)cc1

InChI Key: InChIKey=ULOWIVDVXARWCW-RMKNXTFCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332556   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332556
PNG
((2E)-1-{2-[(2,6-dichlorophenyl)methyl]-2,7-diazasp...)
Show SMILES Clc1cccc(Cl)c1CN1CC2(C1)CCN(CC2)C(=O)\C=C\c1ccc(Br)cc1
Show InChI InChI=1S/C23H23BrCl2N2O/c24-18-7-4-17(5-8-18)6-9-22(29)28-12-10-23(11-13-28)15-27(16-23)14-19-20(25)2-1-3-21(19)26/h1-9H,10-16H2/b9-6+
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair