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BDBM332558 5-chloroindol-2-yl 2-{[3-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-2,7-diazaspiro[3.5]non-7-yl ketone::US10196369, Compound C13

SMILES: Fc1cc(ccc1C(F)(F)F)C(=O)N1CC2(C1)CCN(CC2)C(=O)c1cc2cc(Cl)ccc2[nH]1

InChI Key: InChIKey=BHSQOCWXISFLLD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332558   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332558
PNG
(5-chloroindol-2-yl 2-{[3-fluoro-4-(trifluoromethyl...)
Show SMILES Fc1cc(ccc1C(F)(F)F)C(=O)N1CC2(C1)CCN(CC2)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C24H20ClF4N3O2/c25-16-2-4-19-15(9-16)11-20(30-19)22(34)31-7-5-23(6-8-31)12-32(13-23)21(33)14-1-3-17(18(26)10-14)24(27,28)29/h1-4,9-11,30H,5-8,12-13H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.5n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair