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BDBM332568 (2E)-3-(4-bromophenyl)-1-{7-[(4-(1H-1,2,3,4-tetraazol-5-yl)phenyl)carbonyl]-2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one::US10196369, Compound C23

SMILES: Brc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)c2ccc(cc2)-c2nnn[nH]2)cc1

InChI Key: InChIKey=UKNNLRPDNPGLND-XCVCLJGOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332568   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332568
PNG
((2E)-3-(4-bromophenyl)-1-{7-[(4-(1H-1,2,3,4-tetraa...)
Show SMILES Brc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)c2ccc(cc2)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C24H23BrN6O2/c25-20-8-1-17(2-9-20)3-10-21(32)31-15-24(16-31)11-13-30(14-12-24)23(33)19-6-4-18(5-7-19)22-26-28-29-27-22/h1-10H,11-16H2,(H,26,27,28,29)/b10-3+
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.5n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair