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BDBM332607 7-[(3,5-dimethoxyphenyl)methyl]-2,7-diazaspiro[3.5]non-2-yl 5-bromoindol-2-yl ketone::US10196369, Compound C62

SMILES: COc1cc(CN2CCC3(CN(C3)C(=O)c3cc4cc(Br)ccc4[nH]3)CC2)cc(OC)c1

InChI Key: InChIKey=KCOLTRNDCVOLAR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332607   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332607
PNG
(7-[(3,5-dimethoxyphenyl)methyl]-2,7-diazaspiro[3.5...)
Show SMILES COc1cc(CN2CCC3(CN(C3)C(=O)c3cc4cc(Br)ccc4[nH]3)CC2)cc(OC)c1
Show InChI InChI=1S/C25H28BrN3O3/c1-31-20-9-17(10-21(13-20)32-2)14-28-7-5-25(6-8-28)15-29(16-25)24(30)23-12-18-11-19(26)3-4-22(18)27-23/h3-4,9-13,27H,5-8,14-16H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.5n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair