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BDBM332608 6-bromoindol-2-yl 7-{[4-(trifluoromethyl)phenyl]methyl}-2,7-diazaspiro[3.5]non-2-yl ketone::US10196369, Compound C63

SMILES: FC(F)(F)c1ccc(CN2CCC3(CN(C3)C(=O)c3cc4ccc(Br)cc4[nH]3)CC2)cc1

InChI Key: InChIKey=CIHCRVJZIDTDHB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332608   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 183


(Homo sapiens (Human))
BDBM332608
PNG
(6-bromoindol-2-yl 7-{[4-(trifluoromethyl)phenyl]me...)
Show SMILES FC(F)(F)c1ccc(CN2CCC3(CN(C3)C(=O)c3cc4ccc(Br)cc4[nH]3)CC2)cc1
Show InChI InChI=1S/C24H23BrF3N3O/c25-19-6-3-17-11-21(29-20(17)12-19)22(32)31-14-23(15-31)7-9-30(10-8-23)13-16-1-4-18(5-2-16)24(26,27)28/h1-6,11-12,29H,7-10,13-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...


US Patent US10196369 (2019)

More data for this
Ligand-Target Pair