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BDBM333382 3-[(1R)-1-{[3-(1- Benzofuran-2- yl)imidazo[1,2-b]pyridazin- 6-yl]oxy}-2- (methylamino)ethyl]phenol::US9730929, Example 3

SMILES: CN(C[C@H](O)c1cccc(O)c1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=YJISMXYEZHXAJA-OAGGEKHMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333382   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mknk1 high atp


(Homo sapiens (Human))
BDBM333382
PNG
(3-[(1R)-1-{[3-(1- Benzofuran-2- yl)imidazo[1,2-b]p...)
Show SMILES CN(C[C@H](O)c1cccc(O)c1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18F2N4O2S/c19-11-2-1-10(12(20)7-11)3-4-21-17-18-23-8-13(24(18)6-5-22-17)16-15(26)14(25)9-27-16/h1-2,5-8,14-16,25-26H,3-4,9H2,(H,21,22)/t14-,15-,16+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair