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BDBM333385 3-{[3-(1-Benzofuran-2- yl)imidazo[1,2-b]pyridazin- 6-yl]oxy}-N- methylpropan-1-amine::US9730929, Example 6

SMILES: CN(CCCO)c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=MAFQAHWBXVYORU-OAGGEKHMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333385   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mknk1 high atp


(Homo sapiens (Human))
BDBM333385
PNG
(3-{[3-(1-Benzofuran-2- yl)imidazo[1,2-b]pyridazin-...)
Show SMILES CN(CCCO)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18F2N4O2S/c19-11-5-10(6-12(20)7-11)1-2-21-17-18-23-8-13(24(18)4-3-22-17)16-15(26)14(25)9-27-16/h3-8,14-16,25-26H,1-2,9H2,(H,21,22)/t14-,15-,16+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair