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BDBM333391 (−)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl](methyl)amino}-1-phenylethanol::US9730929, Example 12

SMILES: CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=CJGWPNKFGIMGEJ-KURKYZTESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333391   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mknk1 high atp


(Homo sapiens (Human))
BDBM333391
PNG
((−)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]p...)
Show SMILES CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H22N4O2S/c25-16-11-27-18(17(16)26)15-10-23-20-19(21-6-7-24(15)20)22-9-12-2-1-3-14(8-12)13-4-5-13/h1-3,6-8,10,13,16-18,25-26H,4-5,9,11H2,(H,21,22)/t16-,17-,18+/m1/s1
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Article
US Patent
n/an/a 4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.045
More data for this
Ligand-Target Pair