BindingDB logo
myBDB logout

BDBM333393 1-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl](methyl)amino}propan-2-ol::US9730929, Example 14

SMILES: CC(O)CN(C)c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=LIHPRALJTPDQRZ-NJYVYQBISA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333393   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mknk1 high atp


(Homo sapiens (Human))
BDBM333393
PNG
(1-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CC(O)CN(C)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C23H22N4O3S/c28-19-14-31-21(20(19)29)18-13-26-23-22(24-9-10-27(18)23)25-12-15-5-4-8-17(11-15)30-16-6-2-1-3-7-16/h1-11,13,19-21,28-29H,12,14H2,(H,24,25)/t19-,20-,21+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair