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BDBM333395 2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl](cyclopropyl)amino}-1-phenylethanol::US9730929, Example 16

SMILES: OC(CN(C1CC1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1

InChI Key: InChIKey=OIYYTURYNLJKPH-ZACQAIPSSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333395   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mknk1 high atp


(Homo sapiens (Human))
BDBM333395
PNG
(2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES OC(CN(C1CC1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C18H18ClN3O2S/c19-12-3-1-2-11(8-12)4-5-13-18-21-9-14(22(18)7-6-20-13)17-16(24)15(23)10-25-17/h1-3,6-9,15-17,23-24H,4-5,10H2/t15-,16-,17+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair