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BDBM333397 2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl](cyclopropyl)amino}-1-(4-fluorophenyl)ethanol::US9730929, Example 18

SMILES: OC(CN(C1CC1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccc(F)cc1

InChI Key: InChIKey=SYIHRGXCSLLSBK-KFWWJZLASA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333397   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mknk1 high atp


(Homo sapiens (Human))
BDBM333397
PNG
(2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES OC(CN(C1CC1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccc(F)cc1
Show InChI InChI=1S/C17H16ClFN4O2S/c18-10-1-2-11(19)9(5-10)6-21-16-17-22-7-12(23(17)4-3-20-16)15-14(25)13(24)8-26-15/h1-5,7,13-15,24-25H,6,8H2,(H,20,21)/t13-,14-,15+/m1/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 42n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.045
More data for this
Ligand-Target Pair