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BDBM333400 2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl](isopropyl)amino}-1-phenylethanol::US9730929, Example 21

SMILES: CC(C)N(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=FZFZZBOJQHWVIX-KURKYZTESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333400   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mknk1 high atp


(Homo sapiens (Human))
BDBM333400
PNG
(2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CC(C)N(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H20FN5O3S/c1-11-7-26-21(30-11)13-3-2-12(6-14(13)22)8-24-19-20-25-9-15(27(20)5-4-23-19)18-17(29)16(28)10-31-18/h2-7,9,16-18,28-29H,8,10H2,1H3,(H,23,24)/t16-,17-,18+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair