BindingDB logo
myBDB logout

BDBM333410 4-[5-(2,4-Difluorophenoxy)-2-methyl-1H-benzimidazol-6-yl]-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one trifluoroacetate::US9737516, Example 6

SMILES: Cc1nc2cc(Oc3ccc(F)cc3F)c(cc2[nH]1)-c1cn(C)c(=O)c2[nH]ccc12

InChI Key: InChIKey=JDEUUGSRFPUDFB-ZACQAIPSSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 333410   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))
BDBM333410
PNG
(4-[5-(2,4-Difluorophenoxy)-2-methyl-1H-benzimidazo...)
Show SMILES Cc1nc2cc(Oc3ccc(F)cc3F)c(cc2[nH]1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C18H18ClN3O2S/c19-12-4-1-3-11(7-12)8-20-13-5-2-6-22-14(9-21-18(13)22)17-16(24)15(23)10-25-17/h1-7,9,15-17,20,23-24H,8,10H2/t15-,16-,17+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9737516 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM333410
PNG
(4-[5-(2,4-Difluorophenoxy)-2-methyl-1H-benzimidazo...)
Show SMILES Cc1nc2cc(Oc3ccc(F)cc3F)c(cc2[nH]1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C18H18ClN3O2S/c19-12-4-1-3-11(7-12)8-20-13-5-2-6-22-14(9-21-18(13)22)17-16(24)15(23)10-25-17/h1-7,9,15-17,20,23-24H,8,10H2/t15-,16-,17+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9737516 (2017)

More data for this
Ligand-Target Pair