BDBM333448 N-[4-(3-chloro-4- fluorophenylamino)-7-(2- ((1R,5S,6S)-3-methyl-3- azabicyclo[3.1.0]hexan-6- ylethoxy)quinazolin-6-yl]- acrylamide::US10507209, Compound 8::US9730934, Compound 8

SMILES CN1C[C@H]2[C@H](CCOc3cc4ncnc(Nc5ccc(F)c(Cl)c5)c4cc3NC(=O)C=C)[C@H]2C1

InChI Key InChIKey=UAXLMFNKXDVZKH-XGWQRUHWSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 333448   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333448(N-[4-(3-chloro-4- fluorophenylamino)-7-(2- ((1R,5S...)
Affinity DataIC50:  0.660nMAssay Description:Assay Procedures:The abbreviations used in the following assay have the following meanings:HEPES: hydroxyethyl piperazine ethanesulfonic acid;Brij-35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333448(N-[4-(3-chloro-4- fluorophenylamino)-7-(2- ((1R,5S...)
Affinity DataIC50:  6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333448(N-[4-(3-chloro-4- fluorophenylamino)-7-(2- ((1R,5S...)
Affinity DataIC50:  3.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333448(N-[4-(3-chloro-4- fluorophenylamino)-7-(2- ((1R,5S...)
Affinity DataIC50:  0.660nMAssay Description:Samples:Controls: Gefitinib, erlotinib hydrochloride, purchased from Anqing worldchem Co., LTD.; lapatinib ditosylate, purchased from Taizhou Xingche...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333448(N-[4-(3-chloro-4- fluorophenylamino)-7-(2- ((1R,5S...)
Affinity DataIC50:  6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333448(N-[4-(3-chloro-4- fluorophenylamino)-7-(2- ((1R,5S...)
Affinity DataIC50:  3.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent