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BDBM333460 US9737525, Compound MIND4-22

SMILES: C(Oc1cccc2ccccc12)c1nnc(SCc2ccccc2)n1Cc1ccccc1

InChI Key: InChIKey=RLQOPJULTOCNJH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333460   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NAD-dependent deacetylase sirtuin 2


(Homo sapiens (Human))
BDBM333460
PNG
(US9737525, Compound MIND4-22)
Show SMILES C(Oc1cccc2ccccc12)c1nnc(SCc2ccccc2)n1Cc1ccccc1
Show InChI InChI=1S/C27H23N3OS/c1-3-10-21(11-4-1)18-30-26(28-29-27(30)32-20-22-12-5-2-6-13-22)19-31-25-17-9-15-23-14-7-8-16-24(23)25/h1-17H,18-20H2
PDB
MMDB

NCI pathway
KEGG

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 6.00E+3n/an/an/an/an/an/a



The General Hospital Corporation; The Regents of the University of California

US Patent


Assay Description
Modulation of sirtuin activity by compounds was assessed using the Flour de Lys fluorescent biochemical assay in a 96-well format as described (Outei...


US Patent US9737525 (2017)


Article DOI: 10.1021/jm060727j
More data for this
Ligand-Target Pair