BDBM333555 (R)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(2- hydroxy-3- (4- methylpiperazin- 1- yl)propoxy)- 6- methoxy- quinazolin- 4- yloxy)phenyl) urea::US9730937, Example 100

SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OC[C@H](O)CN1CCN(C)CC1

InChI Key InChIKey=CXNXPVZTJDAJFM-OAQYLSRUSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333555   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333555((R)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(2- h...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333555((R)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(2- h...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333555((R)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(2- h...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent