BDBM333673 1-(3- methoxy-4- (trifluoromethyl) phenyl)- 3-(3-(6- methoxy-7-(2- methoxyethoxy) quinazolin-4- yloxy)phenyl) urea::US9730937, Example 223

SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4ccc(c(OC)c4)C(F)(F)F)c3)c2cc1OC

InChI Key InChIKey=TXLPFIVDCVNKCY-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333673   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333673(1-(3- methoxy-4- (trifluoromethyl) phenyl)- 3-(3-(...)
Affinity DataKd:  375nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333673(1-(3- methoxy-4- (trifluoromethyl) phenyl)- 3-(3-(...)
Affinity DataKd:  750nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333673(1-(3- methoxy-4- (trifluoromethyl) phenyl)- 3-(3-(...)
Affinity DataKd: >1.00E+3nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent